How neurons adapt their connections during changes in activity
Molecular mechanisms of homeostatic synaptic plasticity
This study looks at how brain cells, or neurons, keep working well even when their activity changes, focusing on how they adjust by adding special receptors when they're less active, which is important for healthy brain development and function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University (Charles River Campus) NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11007242 on NIH RePORTER |
What this research studies
This research investigates how neurons maintain stability and function when faced with changes in their activity levels. It focuses on a process called homeostatic synaptic plasticity, where neurons increase certain receptors in response to reduced activity. The study examines the role of specific enzymes and molecular mechanisms that affect the formation of these receptors, particularly in the context of brain development and function. By understanding these processes, researchers aim to uncover how neurons can effectively respond to challenges and maintain proper signaling.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions that involve synaptic plasticity or neuronal activity disruptions.
Not a fit: Patients with acute neurological injuries or conditions unrelated to synaptic plasticity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into treating neurological disorders related to synaptic dysfunction.
How similar studies have performed: Other research has shown promising results in understanding synaptic plasticity, making this approach both relevant and potentially impactful.
Where this research is happening
Boston, United States
- Boston University (Charles River Campus) — Boston, United States (Active)
Researchers
- Principal investigator: Man, Hengye — Boston University (Charles River Campus)
- Study coordinator: Man, Hengye
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.