How neuromelanin affects dopamine neurons in Parkinson's disease.
Official title: Influence of neuromelanin on single dopaminergic neurons in Parkinson's disease.
Funded at Oklahoma Medical Research Foundation · NIH-11050246 · Data updated 2026-11-12
This study is looking at how a dark pigment in brain cells, called neuromelanin, affects the dopamine neurons that are important in Parkinson's disease, using a special mouse model to help find new ways to treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | February 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $616,200 |
| NIH project number | 1R01NS135830-01A1 |
| Project ID | NIH-11050246 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Parkinson's disease, particularly those experiencing motor symptoms.
✕Less likely to help
Patients with Parkinson's disease who do not have significant motor symptoms or those at very early stages of the disease may not benefit from this research.
What this research studies
This research investigates the role of neuromelanin, a dark pigment found in certain brain cells, specifically dopamine neurons that are affected in Parkinson's disease. The study uses a novel mouse model to understand how the accumulation of neuromelanin disrupts the function of these neurons, leading to the symptoms of Parkinson's. By employing advanced techniques, the researchers aim to uncover the cellular and systemic effects of neuromelanin, which could provide insights into new treatment strategies. The collaboration among experienced labs enhances the potential for significant findings in this area.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches that modify the progression of Parkinson's disease rather than just alleviating symptoms.
How similar studies have gone: While the specific approach of studying neuromelanin in this context is novel, related research on neurodegenerative diseases has shown promising results in understanding cellular mechanisms.
Where this research is happening
-
Oklahoma Medical Research Foundation
Oklahoma City, United States Active
Researchers
- Principal investigator: Beckstead, Michael J — Oklahoma Medical Research Foundation
- Study coordinator: Beckstead, Michael J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.