How neural stem cells communicate and function in the developing brain
Distal mRNA localization and translation in neural stem cells of the developing brain
['FUNDING_R37'] · DUKE UNIVERSITY · NIH-10978922
This study looks at special brain cells called radial glia that help organize and support brain development, and it aims to understand how problems with these cells might lead to conditions that affect brain growth, which could help patients and families learn more about neurodevelopmental disorders.
Quick facts
| Phase | ['FUNDING_R37'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-10978922 on ClinicalTrials.gov |
What this research studies
This research investigates the role of radial glia cells, which are neural stem cells in the developing brain, in signaling and organizing their environment. The study focuses on how these cells transport and translate specific mRNAs at their endfeet, which are crucial for proper neuronal organization. By understanding these mechanisms, the research aims to uncover how disruptions in these processes may contribute to neurodevelopmental disorders. Patients may benefit from insights gained about the cellular functions that are essential for brain development.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with neurodevelopmental disorders, particularly those related to autism spectrum disorder.
Not a fit: Patients with fully developed neurological conditions unrelated to neurodevelopmental processes may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for addressing neurodevelopmental disorders such as autism.
How similar studies have performed: Other research has shown promising results in understanding cellular signaling in the brain, suggesting that this approach could yield valuable insights.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SILVER, DEBRA — DUKE UNIVERSITY
- Study coordinator: SILVER, DEBRA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autistic Disorder