How nerve cells interact with supporting cells in the sympathetic nervous system
Official title: Neuron-satellite glia interactions in the sympathetic nervous system
Funded at Johns Hopkins University · NIH-10854978 · Data updated 2026-11-12
This study is looking at how certain nerve cells and support cells in the body work together, which is important for keeping our heart and blood pressure healthy, and it aims to find out how problems in their communication might lead to issues like heart failure and high blood pressure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $549,911 |
| NIH project number | 5R01NS133423-02 |
| Project ID | NIH-10854978 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic heart failure, hypertension, or insulin resistance.
✕Less likely to help
Patients with isolated neurological disorders unrelated to the sympathetic nervous system may not benefit from this research.
What this research studies
This research investigates the interactions between sympathetic neurons and satellite glial cells, which are crucial for the proper functioning of the sympathetic nervous system. By exploring how these cells communicate and develop together, the study aims to uncover the mechanisms that regulate sympathetic output to various organs. The researchers will use advanced techniques to analyze the development and function of these neuron-glia units, focusing on how disruptions in their interactions may lead to disorders like chronic heart failure and hypertension.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating conditions related to sympathetic nervous system dysfunction.
How similar studies have gone: Previous research has shown promising results in understanding neuron-glia interactions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Kuruvilla, Rejji — Johns Hopkins University
- Study coordinator: Kuruvilla, Rejji
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.