How nerve cells connect correctly using the WFIKKN2 signal
Axon guidance through the bifunctional cue WFIKKN2 and its receptors
This research explores how nerve cells in the body find their correct partners to form healthy connections, which is vital for how our nervous system works.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brown University NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project ID | NIH-11093574 on NIH RePORTER |
What this research studies
Our nervous system relies on precise connections between nerve cells to control everything we do, from thinking to moving. When these connections don't form correctly during development, it can lead to various health problems and diseases. This project focuses on a newly identified signal called WFIKKN2 and its receptors, which appear to guide nerve fibers to their proper destinations. By understanding how WFIKKN2 works, we hope to learn more about the fundamental processes that ensure our nervous system is wired correctly.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit individuals with neurological conditions stemming from nerve miswiring.
Not a fit: Patients without neurological conditions related to nerve development or miswiring may not see a direct benefit from this specific basic science research.
Why it matters
Potential benefit: If successful, this work could provide foundational knowledge about nerve development, potentially leading to new ways to understand and treat neurological disorders caused by faulty nerve connections.
How similar studies have performed: This project identifies a novel axon guidance cue, WFIKKN2, suggesting a new direction in understanding nerve wiring mechanisms.
Where this research is happening
Providence, United States
- Brown University — Providence, United States (Active)
Researchers
- Principal investigator: Jaworski, Alexander — Brown University
- Study coordinator: Jaworski, Alexander
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.