How neighborhood stress affects brain decision-making and substance use risk

Structural Stressors, Neurocognition in Reward Related Decision Making and Substance Use Risk

NIH-funded research Columbia University Health Sciences · NIH-11380466

This project looks at how living in disadvantaged neighborhoods affects young people's brain-based decision making and their risk for substance use.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionColumbia University Health Sciences NIH-funded
Lab location1 site (New York, United States)
Project IDNIH-11380466 on NIH RePORTER

What this research studies

If you join, researchers will collect information about the neighborhood where you live, such as local income, education, and exposure to violence, and link that to tests of decision-making and brain activity. You may complete behavioral tasks and brain scans that measure how you respond to rewards and make choices. The team will also ask about family supports like parental monitoring and community features such as the presence of Latine-owned businesses to see whether these help protect young people. A Community Advisory Board will help shape the work so findings can be used to design real-world prevention efforts.

Who could benefit from this research

Good fit: Ideal candidates are adolescents and young adults living in disadvantaged neighborhoods or otherwise at higher risk for substance use.

Not a fit: People who do not live in areas experiencing structural disadvantage or who are not at risk for substance use may not see direct benefits from this work.

Why it matters

Potential benefit: Findings could point to neighborhood, family, or individual prevention strategies to lower youth substance use risk.

How similar studies have performed: Prior research links neighborhood disadvantage to health and brain function, but using brain and behavioral measures to connect neighborhood stressors specifically to youth substance use risk is relatively new.

Where this research is happening

New York, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.