How natural steroid hormones affect communication between organs and the musculoskeletal system
Official title: Endogenous steroid hormones as mediators of interorgan communication with the musculoskeletal system
Funded at Augusta University · NIH-11088180 · Data updated 2026-11-12
This study is looking at how hormones called glucocorticoids, which our bodies produce, affect our bones and muscles as we get older, and it’s for anyone interested in understanding how aging impacts physical health.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project start | May 15, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $427,243 |
| NIH project number | 5U01AG086158-02 |
| Project ID | NIH-11088180 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over the age of 21 who may be experiencing age-related musculoskeletal issues.
✕Less likely to help
Patients under 21 years old or those without any musculoskeletal conditions may not benefit from this research.
What this research studies
This research investigates the role of glucocorticoids, which are hormones produced by the adrenal glands, in the aging process of the musculoskeletal system. It aims to understand how these hormones, which are essential for various body functions, are regulated at the tissue level and how their levels change with age. By studying both young and older adults, the research will explore the effects of these hormones on bone health and muscle function, particularly focusing on how they may contribute to age-related conditions. The methodology includes examining hormone levels and their impact on bone and muscle tissues in both human and mouse models.
Why it matters
Potential benefit: If successful, this research could lead to new insights into preventing or treating age-related musculoskeletal disorders.
How similar studies have gone: Previous research has indicated that understanding the role of hormones in aging can lead to significant advancements in treatment strategies, suggesting potential success for this approach.
Where this research is happening
-
Augusta University
Augusta, United States Active
Researchers
- Principal investigator: Mcgee-Lawrence, Meghan E. — Augusta University
- Study coordinator: Mcgee-Lawrence, Meghan E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.