How natural selection and population structure affect human genetic variation
The impact of natural selection and population structure on human genomic variation
This study looks at how our genes have changed over time due to natural selection and where people live, using a lot of DNA data to help us understand how our ancestors adapted and moved around, which can teach us more about human evolution and genetic diversity.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10830917 on NIH RePORTER |
What this research studies
This research investigates the influence of natural selection and population structure on genetic variation among humans. By analyzing vast amounts of genomic data, including ancient DNA and genotype-phenotype mappings, the project aims to uncover how adaptation, migration, and selection have shaped our genomes over time. The researchers will develop new statistical models and tools to better understand these processes, focusing on identifying signals of adaptation and estimating the impact of linked selection on allele frequencies. This work could provide insights into human evolution and genetic diversity.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are individuals interested in the genetic factors influencing human traits and diseases, particularly those from diverse populations.
Not a fit: Patients with no interest in genetic research or those not affected by genetic conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of human genetics and inform approaches to address genetic diseases and traits.
How similar studies have performed: Previous research in population genetics has shown success in understanding genetic variation and adaptation, making this approach both relevant and promising.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Coop, Graham — University of California at Davis
- Study coordinator: Coop, Graham
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.