How natural progesterone affects immune responses in women
The regulatory role of natural progesterone in barrier immunity
['FUNDING_R01'] · UNIVERSITY OF WASHINGTON · NIH-10895412
This study is looking at how natural progesterone affects the immune system, especially in women, to see how it interacts with other hormones and influences conditions like asthma and rheumatoid arthritis that can change during the menstrual cycle, helping patients understand their health better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10895412 on ClinicalTrials.gov |
What this research studies
This research investigates the role of natural progesterone in regulating immune responses, particularly in the female reproductive tract and beyond. It aims to understand how progesterone interacts with other hormones like estradiol and how these interactions influence inflammatory diseases that may vary throughout the menstrual cycle. By examining the immune effects of progesterone, the study seeks to provide insights into conditions such as asthma and rheumatoid arthritis, which can fluctuate with hormonal changes. Patients may benefit from a better understanding of how their immune responses are affected by hormonal cycles.
Who could benefit from this research
Good fit: Ideal candidates for this research are women experiencing inflammatory diseases that may be influenced by hormonal changes, such as asthma or rheumatoid arthritis.
Not a fit: Patients who are not women or those whose inflammatory conditions are not affected by hormonal changes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved management of inflammatory diseases in women by tailoring treatments based on hormonal fluctuations.
How similar studies have performed: Previous research has indicated that hormonal fluctuations can impact immune responses, suggesting that this approach may yield valuable insights.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HLADIK, FLORIAN — UNIVERSITY OF WASHINGTON
- Study coordinator: HLADIK, FLORIAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus