How natural killer immune cells develop in people and change with uterine cancer
Elucidation of Human Natural Killer Cell Development
['FUNDING_R01'] · OHIO STATE UNIVERSITY · NIH-11322698
This work looks at how natural killer (NK) immune cells form in healthy people and how they change in uterine endometrial cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-11322698 on ClinicalTrials.gov |
What this research studies
This project will map how natural killer (NK) immune cells form and mature in healthy people and in the uterus when endometrial cancer is present. Researchers will compare NK cells from blood, bone marrow, healthy uterine tissue, and uterine tumors using modern lab methods to identify different NK cell types and their molecular signals. They aim to find which developmental programs are normal and which are altered by the tumor microenvironment. Understanding these differences could point to ways to restore NK cell anti-tumor activity or to design new immune-based treatments for endometrial cancer.
Who could benefit from this research
Good fit: Ideal candidates include people with uterine endometrial cancer who can provide tumor and nearby uterine tissue and healthy volunteers who can provide blood or tissue for comparison.
Not a fit: People looking for immediate treatment options, those without uterine cancer, or patients with unrelated conditions are unlikely to receive direct benefit from participating.
Why it matters
Potential benefit: If successful, this work could lead to new immunotherapy approaches or diagnostics that harness or restore NK cells to fight uterine endometrial cancer.
How similar studies have performed: Prior studies have identified NK cell subtypes and informed some NK-based therapies in other cancers, but applying detailed developmental mapping to uterine endometrial cancer is a newer and less-tested approach.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FREUD, AHARON G — OHIO STATE UNIVERSITY
- Study coordinator: FREUD, AHARON G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.