How naltrexone affects immune and viral responses in people with HIV using opioids
The impact of naltrexone treatment on opioid-induced immune and viral dysregulation during HIV-infection
This study is looking at how naltrexone, a medication for opioid use disorder, can help people living with HIV who also struggle with opioid addiction, by understanding how opioid use affects their immune system and overall health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10452590 on NIH RePORTER |
What this research studies
This research investigates the effects of naltrexone treatment on individuals living with HIV who also have opioid use disorders. It aims to understand how chronic opioid use impacts immune function and inflammation in these patients, potentially leading to worse health outcomes. By analyzing clinical samples from participants in a related clinical trial, the study will explore the relationship between opioid exposure and immune dysregulation, as well as the effectiveness of naltrexone in mitigating these effects. The findings could provide insights into better management strategies for this vulnerable population.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who also have a history of opioid use disorders.
Not a fit: Patients who do not have HIV or opioid use disorders are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for individuals with HIV who are also struggling with opioid use, enhancing their overall health and immune function.
How similar studies have performed: Previous research has shown promising results in understanding the interactions between opioids and immune responses in HIV, suggesting that this approach could yield valuable insights.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Lancioni, Christina Louise — Oregon Health & Science University
- Study coordinator: Lancioni, Christina Louise
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.