How N-cadherin affects tumor growth in certain bone cells
N-cadherin in Extraskeletal Osteolineage Cells Modulates Tumor Growth
['FUNDING_R01'] · WASHINGTON UNIVERSITY · NIH-10877024
This study is looking at how a protein called N-cadherin in certain bone cells affects the growth and spread of breast cancer, and it aims to find new ways to understand and treat the disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-10877024 on ClinicalTrials.gov |
What this research studies
This research investigates the role of N-cadherin, a cell adhesion molecule, in the growth of tumors, particularly in breast cancer. It focuses on how N-cadherin in specific bone cells, known as osteolineage cells, influences tumor behavior and metastasis. The researchers are examining the effects of removing the N-cadherin gene in these cells and how it alters tumor growth and spread. By understanding these mechanisms, the study aims to uncover new insights into cancer progression and potential treatment targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with breast cancer, particularly those with advanced disease or metastasis.
Not a fit: Patients with non-breast cancers or those who do not have tumors involving osteolineage cells may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating breast cancer by targeting the mechanisms that tumors use to grow and spread.
How similar studies have performed: Other research has shown that targeting cell adhesion molecules can influence tumor growth, suggesting that this approach may yield significant insights.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CIVITELLI, ROBERTO — WASHINGTON UNIVERSITY
- Study coordinator: CIVITELLI, ROBERTO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Breast Cancer, Breast Cancer Cell