How myosin-3 controls cell movement and sensory cell function
Molecular Mechanisms of Myosin-3
['FUNDING_R01'] · OHIO STATE UNIVERSITY · NIH-11175981
Looking at how the myosin-3 protein works inside cells to help researchers understand problems in sensory cells.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-11175981 on ClinicalTrials.gov |
What this research studies
Researchers will study the myosin-3 protein using purified proteins, cell experiments, and high-resolution structural imaging to see how it interacts with actin and other partners. They will combine biochemical and biophysical tests with live cell studies to map how the protein's motor and kinase parts are regulated. The team will determine enzymatic activity, binding partners, and structural features that control myosin-3 function. This is laboratory-based work aimed at uncovering basic molecular mechanisms rather than testing treatments in people.
Who could benefit from this research
Good fit: People with sensory cell disorders or inherited forms of hearing loss linked to myosin genes might be most likely to benefit from related future clinical research.
Not a fit: Patients with unrelated conditions (for example metabolic, cardiovascular, or psychiatric disorders) are unlikely to receive direct benefit from this laboratory-focused work.
Why it matters
Potential benefit: If successful, this work could point to new targets or strategies for treating sensory cell disorders, such as some forms of inherited hearing loss.
How similar studies have performed: Other myosin family members have been well studied and provided useful insights, but the kinase-myosin hybrid properties of myosin-3 are relatively novel and less well explored.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HEISSLER, SARAH — OHIO STATE UNIVERSITY
- Study coordinator: HEISSLER, SARAH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.