How Myosin 1e helps kidney filters and podocyte health
Role of myosin 1e in podocyte biology and renal filtration
This project looks at whether boosting the Myosin 1e protein can protect the kidney's filter cells (podocytes) and help people with certain kidney diseases keep their kidney function.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Upstate Medical University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project ID | NIH-11235873 on NIH RePORTER |
What this research studies
Researchers will study how disease-linked MYO1E mutations change Myosin 1e behavior using lab-grown cells and purified protein experiments. They will define how the protein turns itself off (autoinhibition) so they can find ways to turn it back on. In animal models they will test whether activating Myosin 1e shields podocytes from damage and preserves filtration. The work is aimed at linking these lab findings to human kidney disease caused by MYO1E problems.
Who could benefit from this research
Good fit: People with genetic MYO1E mutations or podocyte-related kidney diseases (such as certain forms of focal segmental glomerulosclerosis) would be the most directly relevant patients.
Not a fit: Patients whose kidney disease is driven mainly by other causes (for example advanced diabetic or vascular kidney disease) may not benefit from therapies targeting Myosin 1e.
Why it matters
Potential benefit: If successful, this work could lead to therapies that protect podocytes and slow or prevent progression to kidney failure.
How similar studies have performed: Genetic and laboratory studies have linked MYO1E to podocyte disease, but directly activating Myosin 1e as a treatment is largely untested and remains experimental.
Where this research is happening
Syracuse, United States
- Upstate Medical University — Syracuse, United States (Active)
Researchers
- Principal investigator: Krendel, Mira — Upstate Medical University
- Study coordinator: Krendel, Mira
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.