How Mycobacterium tuberculosis uses toxins to survive stress
Transcriptome and proteome remodeling by Mycobacterium tuberculosis MazF toxins
This study is looking at how the tuberculosis bacteria survive tough situations, like our immune system and treatments, by using special proteins, and it aims to find new ways to fight tuberculosis more effectively.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-10738768 on NIH RePORTER |
What this research studies
This research investigates how the bacteria Mycobacterium tuberculosis (Mtb) survives various stresses, including immune responses and treatments aimed at eradicating it. The study focuses on understanding the role of toxin-antitoxin systems, specifically the MazE and MazF proteins, in helping Mtb adapt and potentially enter a dormant state. By employing advanced techniques like 5' RNA sequencing, researchers aim to identify how these toxins affect the bacteria's genetic and protein expression under different conditions. This knowledge could lead to new strategies for combating tuberculosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with latent tuberculosis infections or those at risk of developing tuberculosis.
Not a fit: Patients with active tuberculosis or those who do not have any history of tuberculosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that effectively target and eliminate latent tuberculosis infections.
How similar studies have performed: Other research has shown promise in understanding toxin-antitoxin systems in bacteria, suggesting that this approach could yield valuable insights into tuberculosis treatment.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Woychik, Nancy Ann — Rutgers Biomedical and Health Sciences
- Study coordinator: Woychik, Nancy Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.