How MyBP-C protein affects skeletal muscle and arthrogryposis
Skeletal Myosin-Binding Protein C Regulation and Structural Dynamics
Looking at how changes in a muscle protein called MyBP-C can affect muscle contraction in people with arthrogryposis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project ID | NIH-11388303 on NIH RePORTER |
What this research studies
Researchers are using new fluorescent sensors and biophysical tools to watch how skeletal MyBP-C proteins fold and bind to actin and myosin in muscle. They will test how phosphorylation by PKA and disease-linked MYBPC1/MYBPC2 mutations change MyBP-C structure and its interaction with the contractile machinery. The work is done in the lab on muscle proteins and model muscle systems to pinpoint molecular changes that could lead to joint contractures. Findings may help identify molecular targets for future therapies for distal arthrogryposis.
Who could benefit from this research
Good fit: People with distal arthrogryposis or known MYBPC1/MYBPC2 mutations would be most directly connected to this research.
Not a fit: People whose muscle problems come from causes unrelated to MyBP-C or MYBPC mutations are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, this work could reveal why certain MYBPC mutations cause muscle contractures and point to targets for new treatments for arthrogryposis.
How similar studies have performed: Previous studies on cardiac MyBP-C and basic muscle biophysics have provided useful lessons, but applying fluorescent sensors to skeletal MyBP-C and DA mutations is a relatively new approach.
Where this research is happening
Tucson, United States
- University of Arizona — Tucson, United States (Active)
Researchers
- Principal investigator: Colson, Brett a — University of Arizona
- Study coordinator: Colson, Brett a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.