How mutations and transcription factors interact in blood cell development
Official title: Mutual reinforcement between somatic mutations and transcription factors in clonal hematopoiesis
Funded at Texas A&m University Health Science Ctr · NIH-11002344 · Data updated 2026-11-12
This study is looking at how certain genetic changes affect blood cell development in older adults with specific blood disorders, using lab techniques and patient samples to better understand these changes and their impact on health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University Health Science Ctr NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project start | March 1, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $437,351 |
| NIH project number | 5R01DK132286-03 |
| Project ID | NIH-11002344 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults diagnosed with clonal hematopoiesis or myelodysplastic syndromes.
✕Less likely to help
Patients without clonal hematopoiesis or myelodysplastic syndromes may not receive any benefit from this research.
What this research studies
This research investigates the relationship between specific genetic mutations and transcription factors in the development of blood cells, particularly in older adults with clonal hematopoiesis and myelodysplastic syndromes. By using advanced genetic editing techniques and analyzing bone marrow samples, the researchers aim to understand how these mutations affect the fitness of blood stem and progenitor cells. The study combines laboratory experiments with patient samples to validate findings and explore the underlying mechanisms of clonal expansion in these conditions.
Why it matters
Potential benefit: If successful, this research could lead to new insights and potential treatments for patients with clonal hematopoiesis and myelodysplastic syndromes.
How similar studies have gone: Other research has shown promising results in understanding genetic mutations in blood disorders, making this approach both relevant and potentially impactful.
Where this research is happening
-
Texas A&m University Health Science Ctr
College Station, United States Active
Researchers
- Principal investigator: Huang, Yun — Texas A&m University Health Science Ctr
- Study coordinator: Huang, Yun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.