How mutant ENL affects gene activation in cancer
Official title: Mechanisms of pathogenic gene activation by aberrant transcriptional hubs formed by mutant ENL
Funded at University of Pennsylvania · NIH-10929997 · Data updated 2026-11-12
This study is looking at how changes in a protein called ENL can cause problems with how genes are turned on, which might lead to cancer and other diseases, and it aims to find new ways to treat these conditions by understanding how these changes happen.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 5F31CA284714-02 |
| Project ID | NIH-10929997 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients with cancers linked to ENL mutations or other related transcriptional dysregulations.
✕Less likely to help
Patients without ENL mutations or those with unrelated cancers may not benefit from this research.
What this research studies
This research investigates how mutations in the ENL protein lead to the formation of transcriptional hubs that disrupt normal gene activation processes. By utilizing advanced imaging techniques, the study aims to understand the transient interactions of regulatory proteins with chromatin and how these interactions contribute to cancer and other diseases. The project will explore the mechanisms by which these hubs influence transcription and the kinetics of regulatory proteins, providing insights into potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating cancers associated with ENL mutations by targeting the mechanisms of aberrant gene activation.
How similar studies have gone: While the specific approach of studying ENL-related transcriptional hubs is novel, similar research has shown promise in understanding gene regulation in cancer.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Mathias, Kaeli Marie — University of Pennsylvania
- Study coordinator: Mathias, Kaeli Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.