How mutant blood cells affect health in older adults
Official title: Cellular Interactions and Competition in Clonal Hematopoiesis
Funded at Baylor College of Medicine · NIH-10998269 · Data updated 2026-11-12
This study is looking at how certain gene changes in blood cells affect older adults' health, especially those over 55, to help us understand how these changes might lead to age-related diseases and improve care for those at risk.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $49,821 |
| NIH project number | 1F30HL172468-01A1 |
| Project ID | NIH-10998269 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults, particularly those over the age of 55, who may have detectable clonal hematopoiesis.
✕Less likely to help
Patients under the age of 55 or those without detectable clonal hematopoiesis are unlikely to benefit from this research.
What this research studies
This research investigates clonal hematopoiesis (CH), a condition where blood cells expand from a single mutated stem cell, particularly in individuals over 55. It aims to understand how different mutations in genes like Dnmt3a, Tet2, and Asxl1 influence the behavior of these mutant cells and their impact on age-related diseases. By studying the interactions between these mutant clones and their response to inflammation, the research seeks to uncover the mechanisms that drive their survival and proliferation. This knowledge could lead to better understanding and management of health risks associated with aging.
Why it matters
Potential benefit: If successful, this research could provide insights into preventing or managing age-related diseases linked to clonal hematopoiesis.
How similar studies have gone: Previous studies have shown that understanding the behavior of mutant clones in isolation can provide valuable insights, suggesting that this research could build on established findings.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Thatavarty, Apoorva — Baylor College of Medicine
- Study coordinator: Thatavarty, Apoorva
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.