How muscle fatigue affects walking in older adults

Muscle Fatigue and its Impact on Mobility Function in Aging

NIH-funded research University of Massachusetts Amherst · NIH-10662460

This study is looking at how tired muscles affect the ability to move around in older adults, especially those over 65, to find ways to help them walk better and enjoy life more.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Massachusetts Amherst NIH-funded
Lab location1 site (Hadley, United States)
Project IDNIH-10662460 on NIH RePORTER

What this research studies

This research investigates the relationship between muscle fatigue and mobility function in older adults, particularly those over 65 years of age. It aims to understand how impaired energy production in muscle cells contributes to increased fatigue during activities like walking. By using advanced imaging techniques, the study will explore the cellular and molecular mechanisms behind muscle fatigue and its impact on mobility. The ultimate goal is to identify ways to improve mobility and quality of life for older individuals experiencing these issues.

Who could benefit from this research

Good fit: Ideal candidates for this research are older adults aged 65 and above who experience mobility issues or increased muscle fatigue.

Not a fit: Patients under 65 years of age or those without mobility dysfunction may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved strategies for enhancing mobility and reducing fatigue in older adults.

How similar studies have performed: Previous research has shown that understanding muscle fatigue mechanisms can lead to significant improvements in mobility for older adults, indicating that this approach has potential for success.

Where this research is happening

Hadley, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.