How muscle and bone healing is affected by lack of movement
Mechanobiology of fracture healing during skeletal disuse
['FUNDING_CAREER'] · VIRGINIA COMMONWEALTH UNIVERSITY · NIH-10907021
This study looks at how not moving enough can slow down healing from fractures and tests different ways to help bones heal better, which could lead to new treatments for people recovering from broken bones.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VIRGINIA COMMONWEALTH UNIVERSITY (nih funded) |
| Locations | 1 site (RICHMOND, UNITED STATES) |
| Trial ID | NIH-10907021 on ClinicalTrials.gov |
What this research studies
This research investigates how decreased muscle and bone strength from lack of movement impacts fracture healing. It uses a mouse model to simulate the effects of disuse on bone repair and explores how different mechanical loading strategies can enhance healing. By understanding the cellular and molecular changes that occur during this process, the study aims to identify effective interventions that could improve recovery outcomes for patients with fractures. The findings could lead to new therapies that address both muscle and bone health during recovery.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced fractures and are at risk of impaired healing due to muscle loss from inactivity.
Not a fit: Patients with stable bone health and no history of fractures or mobility issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for fracture healing, particularly in patients with reduced mobility.
How similar studies have performed: Previous research has shown promise in understanding the role of mechanical loading in bone healing, but this specific approach is relatively novel.
Where this research is happening
RICHMOND, UNITED STATES
- VIRGINIA COMMONWEALTH UNIVERSITY — RICHMOND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BUETTMANN, EVAN G — VIRGINIA COMMONWEALTH UNIVERSITY
- Study coordinator: BUETTMANN, EVAN G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.