How multiple myeloma tumors and immune surroundings differ by ancestry
Differences in Tumor Biology of Multiple Myeloma
This project compares tumor genetics and immune features in multiple myeloma patients with African versus European ancestry to find links to treatment response and survival.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11188968 on NIH RePORTER |
What this research studies
If you join, researchers will collect tumor samples, blood, and clinical information from newly diagnosed multiple myeloma patients of differing genetic ancestry. They will sequence tumor DNA and profile the tumor microenvironment to measure immune and cellular features. The team will compare how often specific high-risk genetic changes and immune patterns occur in patients with African versus European ancestry. They will also look at how these biological differences relate to treatment results and overall survival.
Who could benefit from this research
Good fit: Ideal candidates are adults newly diagnosed with multiple myeloma who can provide tumor samples, blood, and clinical data, particularly patients of African or European ancestry.
Not a fit: People without multiple myeloma or those unwilling/unable to provide samples or clinical follow-up would not benefit directly from this project.
Why it matters
Potential benefit: If successful, this work could inform more personalized treatment plans and better survival predictions for patients of different ancestries.
How similar studies have performed: Prior genomic studies in multiple myeloma have found risk variants and treatment markers, but large, direct comparisons of tumor genetics and the tumor microenvironment by ancestry remain relatively new.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Baughn, Linda B — Mayo Clinic Rochester
- Study coordinator: Baughn, Linda B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.