How morphine and HIV affect opioid receptor gene splicing
Modulation of OPRM1 alternative splicing by morphine and HIV-1 Nef
This study is looking at how HIV and morphine work together in the body and how that affects a gene important for how opioids work, to help us understand why people with HIV might struggle more with opioid dependence.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10871854 on NIH RePORTER |
What this research studies
This research investigates how the interaction between HIV and morphine influences the splicing of the OPRM1 gene, which is crucial for opioid signaling. By examining the molecular mechanisms involved, the study aims to understand why individuals with HIV may experience increased dependence on opioids. The research utilizes advanced techniques to analyze the expression of different OPRM1 isoforms in neuronal cells and postmortem brain tissues from people living with HIV. This could provide insights into the biological underpinnings of opioid addiction in this population.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who also have a history of opioid use or dependence.
Not a fit: Patients who do not have HIV or a history of opioid use may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment strategies for opioid dependence in individuals living with HIV.
How similar studies have performed: While the specific interactions between HIV and morphine in OPRM1 splicing are novel, related research has shown that drug interactions can significantly affect gene expression and addiction pathways.
Where this research is happening
Philadelphia, United States
- Temple Univ of the Commonwealth — Philadelphia, United States (Active)
Researchers
- Principal investigator: Sariyer, Ilker Kudret — Temple Univ of the Commonwealth
- Study coordinator: Sariyer, Ilker Kudret
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.