How morning insulin delivery affects glucose metabolism later in the day
Official title: The Impact of Morning Insulin Delivery on Hepatic Glucose Metabolism Later in the Day
Funded at Vanderbilt University · NIH-11067971 · Data updated 2026-11-12
This study is looking at how different ways of giving insulin in the morning can affect how well the body controls blood sugar after meals later in the day, and it's designed for people with diabetes who want to learn more about managing their condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project start | January 1, 2025 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $35,772 |
| NIH project number | 1F31DK142297-01 |
| Project ID | NIH-11067971 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with insulin-dependent diabetes who are 21 years or older.
✕Less likely to help
Patients who do not have insulin-dependent diabetes or are under 21 years old may not benefit from this research.
What this research studies
This research investigates how the method of insulin delivery in the morning influences the body's ability to manage glucose levels after meals later in the day. By comparing two different delivery methods—portal vein infusion, which mimics natural insulin secretion, and peripheral infusion, which is commonly used in diabetes treatment—the study aims to understand the effects on liver function and glucose uptake. The research involves complex metabolic experiments conducted in a controlled setting using a canine model to gather insights that could be applicable to human diabetes management.
Why it matters
Potential benefit: If successful, this research could lead to improved insulin delivery methods that enhance glucose control for individuals with insulin-dependent diabetes.
How similar studies have gone: Previous research has shown promising results in understanding insulin delivery methods, but this specific approach using a canine model is relatively novel.
Where this research is happening
-
Vanderbilt University
Nashville, United States Active
Researchers
- Principal investigator: Waterman, Hannah Lynn — Vanderbilt University
- Study coordinator: Waterman, Hannah Lynn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.