How molecular chaperones help proteins function in the cell nucleus
Regulation of the Native Protein Landscape in the Nucleus by Molecular Chaperones
['FUNDING_OTHER'] · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · NIH-11100326
This study looks at how special helpers in our cells, called molecular chaperones, support proteins in the cell nucleus to work properly and adapt to changes, which is important for keeping our cells healthy and functioning well.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN (nih funded) |
| Locations | 1 site (CHAMPAIGN, UNITED STATES) |
| Trial ID | NIH-11100326 on ClinicalTrials.gov |
What this research studies
This research investigates the role of molecular chaperones, specifically the Hsp90 chaperone system, in maintaining the proper functioning of proteins within the cell nucleus. It aims to understand how these chaperones assist in the dynamic interactions of proteins, ensuring that they can quickly respond to changes in the cellular environment. By studying the mechanisms of protein interactions and the disassembly of biological complexes, the research seeks to uncover how cells maintain homeostasis and manage cellular processes effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions linked to protein misfolding or cellular dysfunction, such as neurodegenerative diseases.
Not a fit: Patients with conditions unrelated to protein function or cellular processes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing cellular function and treating diseases related to protein misfolding or dysfunction.
How similar studies have performed: Other research has shown promising results in understanding the role of molecular chaperones in cellular processes, indicating that this approach has potential for success.
Where this research is happening
CHAMPAIGN, UNITED STATES
- UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN — CHAMPAIGN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FREEMAN, BRIAN C — UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
- Study coordinator: FREEMAN, BRIAN C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.