How molecular chaperones help control cell metabolism
Official title: Molecular Chaperone-mediated Regulated of Cell Metabolism
Funded at University of Iowa · NIH-11221188 · Data updated 2026-11-12
This study is looking at how special helpers in our cells, called molecular chaperones, keep proteins healthy and help our cells use energy properly, which could lead to better understanding of diseases like cancer and neurological disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $280,562 |
| NIH project number | 7R35GM150481-03 |
| Project ID | NIH-11221188 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by neurological diseases or cancers linked to protein aggregation.
✕Less likely to help
Patients with conditions unrelated to protein metabolism or aggregation may not benefit from this research.
What this research studies
This research investigates the role of molecular chaperones in maintaining protein health and regulating cell metabolism. By using advanced imaging techniques and biochemical methods, the study aims to understand how these chaperones assist in the proper functioning of metabolic enzymes, which are crucial for cell survival and growth. The research will explore how chaperones influence enzyme behavior, including their assembly and degradation, to ensure efficient metabolic processes. This could provide insights into the underlying mechanisms of diseases linked to protein aggregation, such as neurological disorders and cancers.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases associated with protein misfolding and metabolic dysfunction.
How similar studies have gone: While the specific approach of this research is novel, there is a growing body of evidence supporting the importance of molecular chaperones in cellular processes, indicating potential for significant findings.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Pedley, Anthony M — University of Iowa
- Study coordinator: Pedley, Anthony M
Related research
Other NIH-funded projects on the same topics.
-
Healthier Workplace Center for the Midwest
A multi-site NIH grant aims to improve the health and well-being of workers by coordinating research and sharing evidence-based strategies.
-
Serotonin pathways and how they help recovery after seizures
A researcher is studying how serotonin-related brain circuits influence waking up after seizures, using mouse models to understand why some people with epilepsy have dangerous breathing pauses after seizures.
-
Serotonin brain circuit clues to safer sleep after seizures
Aims to understand how brain serotonin systems and CO2-triggered arousal affect recovery after seizures in mouse models to reduce SUDEP risk.
-
Improved ICU Mobility Care through a Smart Guideline in the EHR
A hospital study will test a smart tool in the electronic health record to help ICU teams identify when to start patient-friendly mobility activities and coordinate a plan tailored to each patient.
-
Ultrasound biomarkers to diagnose and predict treatment response for plantar heel pain
A study will test advanced ultrasound imaging to find biomarkers that help diagnose plantar heel pain and predict who will respond to targeted treatments.
-
Pain and aging: how nerve cells become more sensitive with age
This project looks at why older adults often have chronic pain by studying how nerve cells in aging animals become more sensitive and how inflammation might drive this change.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.