How molecular chaperones help control cell metabolism
Molecular Chaperone-mediated Regulated of Cell Metabolism
['FUNDING_OTHER'] · UNIVERSITY OF IOWA · NIH-11221188
This study is looking at how special helpers in our cells, called molecular chaperones, keep proteins healthy and help our cells use energy properly, which could lead to better understanding of diseases like cancer and neurological disorders.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF IOWA (nih funded) |
| Locations | 1 site (IOWA CITY, UNITED STATES) |
| Trial ID | NIH-11221188 on ClinicalTrials.gov |
What this research studies
This research investigates the role of molecular chaperones in maintaining protein health and regulating cell metabolism. By using advanced imaging techniques and biochemical methods, the study aims to understand how these chaperones assist in the proper functioning of metabolic enzymes, which are crucial for cell survival and growth. The research will explore how chaperones influence enzyme behavior, including their assembly and degradation, to ensure efficient metabolic processes. This could provide insights into the underlying mechanisms of diseases linked to protein aggregation, such as neurological disorders and cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by neurological diseases or cancers linked to protein aggregation.
Not a fit: Patients with conditions unrelated to protein metabolism or aggregation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases associated with protein misfolding and metabolic dysfunction.
How similar studies have performed: While the specific approach of this research is novel, there is a growing body of evidence supporting the importance of molecular chaperones in cellular processes, indicating potential for significant findings.
Where this research is happening
IOWA CITY, UNITED STATES
- UNIVERSITY OF IOWA — IOWA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PEDLEY, ANTHONY M — UNIVERSITY OF IOWA
- Study coordinator: PEDLEY, ANTHONY M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.