How modifications to certain enzymes affect DNA repair during cancer treatment
Official title: Post-translational modifications control JARID enzyme activity during DNA damage
Funded at Ut Southwestern Medical Center · NIH-10977473 · Data updated 2026-11-12
This study is looking at how certain changes in specific enzymes affect their ability to help repair DNA damage caused by radiation therapy, with the goal of making treatment more effective for people with non-small cell lung cancer.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $74,864 |
| NIH project number | 3R03CA273480-02S1 |
| Project ID | NIH-10977473 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with non-small cell lung cancer who are undergoing or considering radiation therapy.
✕Less likely to help
Patients with cancers other than non-small cell lung cancer or those not receiving radiation therapy may not benefit from this research.
What this research studies
This research investigates how post-translational modifications of JARID enzymes influence their activity during DNA damage, particularly in the context of radiation therapy for non-small cell lung cancer (NSCLC). By understanding these modifications, the study aims to enhance the effectiveness of radiation therapy, which is commonly used but often not curative on its own. The approach involves examining the role of these enzymes in DNA repair pathways, which could lead to improved treatment strategies for patients with NSCLC. The research utilizes advanced techniques to analyze how these enzymes interact with chromatin and DNA repair mechanisms after radiation exposure.
Why it matters
Potential benefit: If successful, this research could lead to more effective radiation therapies for patients with non-small cell lung cancer, potentially improving survival rates.
How similar studies have gone: Previous research has shown promising results in enhancing cancer treatment through targeted modifications of DNA repair pathways, suggesting that this approach could be effective.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Martinez, Elisabeth D — Ut Southwestern Medical Center
- Study coordinator: Martinez, Elisabeth D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.