How modifications to certain enzymes affect DNA repair during cancer treatment
Official title: Post-translational modifications control JARID enzyme activity during DNA damage
Funded at Ut Southwestern Medical Center · NIH-10793590 · Data updated 2026-11-12
This study is looking at how certain changes in specific enzymes can help improve radiation therapy for patients with non-small cell lung cancer, aiming to make the treatment more effective against tough cancer cells.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $82,000 |
| NIH project number | 5R03CA273480-02 |
| Project ID | NIH-10793590 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with non-small cell lung cancer who are undergoing radiation therapy.
✕Less likely to help
Patients with cancers other than non-small cell lung cancer may not receive benefits from this research.
What this research studies
This research investigates how post-translational modifications of JARID enzymes influence their activity in response to DNA damage caused by radiation therapy in non-small cell lung cancer (NSCLC) patients. By understanding these modifications, the study aims to enhance the effectiveness of radiation therapy, which is commonly used in treating NSCLC. The approach involves examining the role of these enzymes in DNA repair pathways, potentially leading to improved treatment strategies. Patients may benefit from insights that could make radiation therapy more effective against resistant cancer cells.
Why it matters
Potential benefit: If successful, this research could lead to more effective radiation therapies for patients with non-small cell lung cancer, potentially improving treatment outcomes.
How similar studies have gone: Previous research has shown promising results in enhancing cancer treatment through targeted modifications in DNA repair pathways, suggesting that this approach may yield significant advancements.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Martinez, Elisabeth D — Ut Southwestern Medical Center
- Study coordinator: Martinez, Elisabeth D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.