How modifications in ribosomal RNA affect protein production
Official title: The role of rRNA modifications in regulation of translation initiation
Funded at Emory University · NIH-11071141 · Data updated 2026-11-12
This study is looking at how certain changes in a type of RNA called ribosomal RNA affect how proteins are made in cells, which is really important for keeping cells healthy, and it's being done using yeast to help us understand how these changes might be different in conditions like cancer and neurological disorders.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | March 1, 2025 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 1F31GM157874-01 |
| Project ID | NIH-11071141 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to abnormal protein synthesis, including certain cancers and neurological disorders.
✕Less likely to help
Patients with conditions unrelated to protein synthesis regulation may not benefit from this research.
What this research studies
This research investigates the role of specific chemical modifications in ribosomal RNA (rRNA) and how they influence the initiation of protein synthesis, a critical process for cell function and survival. By using the model organism budding yeast, the study aims to uncover the dynamic nature of these modifications and their variations across different tissues and conditions, including cancer and neurological disorders. The research employs advanced biochemical techniques to analyze rRNA modifications and their impact on translation regulation, which could provide insights into the underlying mechanisms of various diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases linked to dysregulated protein synthesis, such as cancer and neurological disorders.
How similar studies have gone: Previous research has shown promising results in understanding the role of rRNA modifications in translation regulation, indicating that this approach has potential for significant findings.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Cureton, Lauryn — Emory University
- Study coordinator: Cureton, Lauryn
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.