How mitochondrial structure affects neuron health and survival
Molecular Regulations of Mitochondrial Structure in Neuronal Homeostasis and Survival
This study is looking at how a protein called MIC60 helps keep brain cells healthy and working well, especially when they face challenges, and it uses fruit flies to find clues that might help us understand brain health in people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11078713 on NIH RePORTER |
What this research studies
This research investigates the role of mitochondrial structure in maintaining the health and function of neurons, which are critical for brain activity. It focuses on a specific protein, MIC60, and how its modifications can influence mitochondrial performance in response to energy demands and stress. By studying these mechanisms in fruit flies, the researchers aim to uncover insights that could be relevant to human neurological conditions. The approach includes examining how changes in MIC60 affect neuronal function and resilience against damage.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with neurodegenerative diseases, particularly those related to mitochondrial dysfunction.
Not a fit: Patients with neurodegenerative conditions unrelated to mitochondrial dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for protecting neurons and treating neurodegenerative diseases like Alzheimer's and ALS.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial roles in neuronal health, suggesting that this approach could yield valuable insights.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Wang, Xinnan — Stanford University
- Study coordinator: Wang, Xinnan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.