How mitochondrial structure affects liver cell health and injury
Impact of mitochondrial structure on cellular homeostasis and hepatic injury
['FUNDING_OTHER'] · WAKE FOREST UNIVERSITY HEALTH SCIENCES · NIH-10827918
This study is looking at how the shape and function of tiny parts of our cells called mitochondria can help keep liver cells healthy and prevent damage, especially when the body faces different challenges like stress or changes in nutrients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WAKE FOREST UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (WINSTON-SALEM, UNITED STATES) |
| Trial ID | NIH-10827918 on ClinicalTrials.gov |
What this research studies
This research investigates the role of mitochondrial structure in maintaining cell health and preventing liver injury. It focuses on how mitochondria interact with other cellular components and respond to various signals, such as nutrient levels and stress. By studying these interactions, the research aims to understand how changes in mitochondrial shape can influence cell survival and death, particularly in liver cells. The approach includes examining calcium dynamics and mitochondrial behavior in response to different physiological conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with liver conditions or those at risk of liver injury due to metabolic or environmental factors.
Not a fit: Patients with non-hepatic conditions or those whose liver function is not affected by mitochondrial dynamics may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for protecting liver cells from injury and improving overall liver health.
How similar studies have performed: Other research has shown promising results in understanding mitochondrial function and its impact on cell health, suggesting that this approach could yield valuable insights.
Where this research is happening
WINSTON-SALEM, UNITED STATES
- WAKE FOREST UNIVERSITY HEALTH SCIENCES — WINSTON-SALEM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TOMAR, DHANENDRA — WAKE FOREST UNIVERSITY HEALTH SCIENCES
- Study coordinator: TOMAR, DHANENDRA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.