How mitochondrial stress affects the body's response to bacterial infections
Mitochondrial stress shapes host responses to bacterial infection
This study is looking at how a special fat called cardiolipin affects the immune system's ability to fight off bacterial infections, especially in people with conditions like Barth syndrome, to help find better treatments for infections like MRSA.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11109553 on NIH RePORTER |
What this research studies
This research investigates how mitochondrial stress influences the immune response to bacterial infections, particularly focusing on a lipid called cardiolipin. The study aims to understand the mechanisms by which cardiolipin changes location and function during infections, which could impact how the body fights off bacteria like methicillin-resistant Staphylococcus aureus (MRSA). By examining these processes in both laboratory settings and living organisms, the research seeks to uncover new insights into immune responses that could lead to better treatments for infections. Patients with conditions like Barth syndrome, which is linked to mitochondrial dysfunction, may particularly benefit from this research.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with mitochondrial disorders, such as Barth syndrome, who experience recurrent bacterial infections.
Not a fit: Patients with non-bacterial infections or those without mitochondrial dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing the immune response against bacterial infections.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial roles in immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: O'riordan, Mary — University of Michigan at Ann Arbor
- Study coordinator: O'riordan, Mary
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.