How mitochondrial stress affects immune cells in tumors
Mitochondrial stress promotes immunosuppressive potential of myeloid subsets in tumors
['FUNDING_R01'] · H. LEE MOFFITT CANCER CTR & RES INST · NIH-10903945
This study is looking at how stress in tiny parts of cells called mitochondria affects immune cells in tumors, especially those that can weaken the body's ability to fight cancer, with the goal of finding new ways to boost the immune response against tumors and make cancer treatments work better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | H. LEE MOFFITT CANCER CTR & RES INST (nih funded) |
| Locations | 1 site (TAMPA, UNITED STATES) |
| Trial ID | NIH-10903945 on ClinicalTrials.gov |
What this research studies
This research investigates how stress in mitochondria influences the behavior of immune cells within tumors, particularly focusing on myeloid cells that can suppress immune responses. The study aims to understand the mechanisms by which these immune cells become immunosuppressive in the tumor microenvironment, which is crucial for tumor growth. By examining the effects of various stress conditions on these cells, the research seeks to identify new therapeutic strategies to enhance anti-tumor immunity and improve the effectiveness of immunotherapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients who are experiencing advanced malignancies and may benefit from improved immunotherapy options.
Not a fit: Patients with early-stage cancers or those not undergoing immunotherapy may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the immune system's ability to fight cancer.
How similar studies have performed: Previous research has shown promising results in targeting immune cell behavior in tumors, suggesting that this approach could lead to significant advancements in cancer treatment.
Where this research is happening
TAMPA, UNITED STATES
- H. LEE MOFFITT CANCER CTR & RES INST — TAMPA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RODRIGUEZ, PAULO CESAR — H. LEE MOFFITT CANCER CTR & RES INST
- Study coordinator: RODRIGUEZ, PAULO CESAR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Induction, Cancer Patient, Cancers