How mitochondrial proteins affect ovarian cancer spread and survival
Regulation of mitochondrial redox homeostasis and signaling in metastatic ovarian cancer
This study is looking at how specific proteins in ovarian cancer cells help them survive and grow when they move away from their usual surroundings, with the hope of finding new treatment options that could make a difference for patients with advanced ovarian cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10817832 on NIH RePORTER |
What this research studies
This research investigates how certain mitochondrial proteins help ovarian cancer cells survive and spread in the body, particularly when they detach from their usual environment. The study focuses on two key proteins, superoxide dismutase 2 (Sod2) and SIRT3, which are believed to play crucial roles in enabling cancer cells to adapt to stressful conditions. By understanding the mechanisms behind these adaptations, the research aims to uncover potential new targets for treatment that could improve patient outcomes. Patients may benefit from insights that could lead to more effective therapies for advanced ovarian cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with late-stage ovarian cancer, particularly those experiencing metastatic spread.
Not a fit: Patients with early-stage ovarian cancer or those with non-ovarian cancers are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that improve survival rates for patients with metastatic ovarian cancer.
How similar studies have performed: Other research has shown promising results in targeting mitochondrial functions in cancer, suggesting that this approach may lead to significant advancements in treatment.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Hempel, Nadine — University of Pittsburgh at Pittsburgh
- Study coordinator: Hempel, Nadine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.