How mitochondrial problems in blood vessel cells affect inflammation and injury in the lungs
Mitochondrial Dysfunction in the Endothelium as a Mediator of Inflammatory Injury
This study is looking at how problems with tiny energy factories in our cells can affect the blood vessels in our lungs, and it aims to find out how cleaning up damaged parts can help our lungs heal and fight off infections better.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-10914679 on NIH RePORTER |
What this research studies
This research investigates how dysfunction in mitochondria, the energy-producing structures in cells, affects the endothelial cells that line blood vessels, particularly in the lungs. It aims to understand the mechanisms behind mitochondrial injury and how the process of mitophagy, or the removal of damaged mitochondria, can help restore normal function and support the immune response during lung injury. By using advanced biosensors, the study will explore how these processes influence inflammation and the behavior of immune cells like neutrophils. The ultimate goal is to identify potential therapeutic targets to improve lung health and recovery from injury.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing inflammatory lung conditions, such as those with acute respiratory distress syndrome or other related cardiovascular diseases.
Not a fit: Patients with chronic lung diseases that do not involve acute inflammatory responses may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance lung recovery and improve outcomes for patients suffering from inflammatory lung injuries.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial dysfunction in various diseases, suggesting that this approach could yield valuable insights and potential breakthroughs.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Rehman, Jalees — University of Illinois at Chicago
- Study coordinator: Rehman, Jalees
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.