How mitochondrial problems affect exercise in patients with severe kidney disease
Role of Mitochondrial Dysfunction in the Response to Exercise in Patients with Advanced Kidney Disease
This study looks at how problems with tiny energy factories in your cells, called mitochondria, affect how well people with advanced kidney disease can benefit from exercise, especially those on hemodialysis who often feel weak and lose muscle; the goal is to find out why exercise might not work as well for you and to create better exercise plans to help improve your health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10912749 on NIH RePORTER |
What this research studies
This research investigates how mitochondrial dysfunction impacts the ability of patients with advanced kidney disease to respond to exercise. It focuses on individuals undergoing hemodialysis, who often experience frailty and muscle loss. By examining the relationship between exercise and mitochondrial health, the study aims to understand why exercise is less effective for these patients compared to the general population. The approach includes assessing mitochondrial function and content in muscle tissue, potentially leading to tailored exercise recommendations for better health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with end-stage renal disease who are undergoing hemodialysis.
Not a fit: Patients with early-stage kidney disease or those not on hemodialysis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could help improve exercise effectiveness and overall health in patients with advanced kidney disease.
How similar studies have performed: Previous research has shown that improving mitochondrial function can enhance exercise outcomes in other populations, suggesting potential for success in this area as well.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Gamboa, Jorge Luis — Vanderbilt University Medical Center
- Study coordinator: Gamboa, Jorge Luis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.