How mitochondrial metabolism affects the speed of development in different mammals
Official title: Role of Mitochondrial Metabolism in Regulating Species-Specific Developmental Rates
Funded at Massachusetts General Hospital · NIH-10852490 · Data updated 2026-11-12
This study looks at how the energy production in cells affects how quickly mammal embryos grow, using a lab setup that simulates the development of mice and humans, to help us understand why different species develop at different speeds.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $578,254 |
| NIH project number | 1R01GM153752-01 |
| Project ID | NIH-10852490 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in the biological mechanisms of development, particularly those with conditions related to developmental delays.
✕Less likely to help
Patients with conditions unrelated to developmental biology or those not interested in the underlying mechanisms of development may not benefit from this research.
What this research studies
This research investigates the differences in developmental rates among mammalian embryos, focusing on how mitochondrial metabolism influences these rates. By using an in vitro system that mimics the developmental processes of mice and humans, the researchers aim to measure and compare the metabolic rates and their effects on development. The study will explore key questions about why metabolic rates differ between species and how these differences impact gene expression and developmental timing.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of developmental biology, potentially informing treatments for developmental disorders.
How similar studies have gone: Previous research has shown success in understanding metabolic differences in developmental biology, suggesting that this approach may yield valuable insights.
Where this research is happening
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Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Diaz Cuadros, Margarete — Massachusetts General Hospital
- Study coordinator: Diaz Cuadros, Margarete
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.