How mitochondrial health affects inflammation and organ function in children with sepsis
Official title: Effect of Mitochondrial Quality Control on Systemic Inflammation and Organ Dysfunction in Pediatric Sepsis
Funded at Nemours Children's Hospital, Delaware · NIH-10861029 · Data updated 2026-11-12
This study is looking at how problems with tiny parts of cells called mitochondria affect children with sepsis, a serious illness, and aims to find ways to help improve their treatment by checking the health of these mitochondria in their blood.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Nemours Children's Hospital, Delaware NIH-funded |
| Lab location | 1 site (Wilmington, United States) |
| Project start | September 1, 2020 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $398,887 |
| NIH project number | 5R01HD102396-06 |
| Project ID | NIH-10861029 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who are diagnosed with sepsis or septic shock.
✕Less likely to help
Patients who are not diagnosed with sepsis or are older than 11 years may not benefit from this research.
What this research studies
This research investigates the role of mitochondrial quality control in children suffering from sepsis, a serious condition that can lead to multiple organ dysfunction. The study focuses on understanding how mitochondrial dysfunction contributes to systemic inflammation and organ failure in pediatric patients. By analyzing blood samples from children with sepsis, researchers aim to identify specific mitochondrial processes that may be disrupted, which could help in developing targeted therapies. The approach includes measuring mitochondrial respiration and content in blood cells to assess their health and functionality.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve outcomes for children with sepsis and reduce the incidence of organ dysfunction.
How similar studies have gone: Previous research has shown that mitochondrial dysfunction is a significant factor in sepsis, suggesting that this approach could yield valuable insights and potential breakthroughs.
Where this research is happening
-
Nemours Children's Hospital, Delaware
Wilmington, United States Active
Researchers
- Principal investigator: Weiss, Scott L — Nemours Children's Hospital, Delaware
- Study coordinator: Weiss, Scott L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.