How mitochondrial genetics affects bone health
Mitochondrial genetics as a determinant of bone health
This study is looking at how the genetics of tiny energy factories in our cells, called mitochondria, can affect bone health, especially how they influence the cells that build bone, which could help us understand bone problems in people with certain genetic conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10706978 on NIH RePORTER |
What this research studies
This research investigates the role of mitochondrial genetics in determining bone health, specifically how different mitochondrial DNA haplotypes influence the function of bone-forming cells called osteoblasts and their precursors. By using a unique genetic model involving mice with varying mitochondrial DNA, the study aims to understand the relationship between mitochondrial function and bone density. The researchers will explore how mitochondrial dysfunction may contribute to bone aging and fragility, particularly in patients with mitochondrial diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of mitochondrial diseases or those experiencing bone health issues, especially related to aging.
Not a fit: Patients with no known mitochondrial issues or those without bone health concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into preventing and treating bone-related conditions, particularly in aging populations.
How similar studies have performed: While the specific approach of using mitochondrial genetics in bone health is relatively novel, there is existing research indicating that mitochondrial function plays a significant role in various physiological processes, suggesting potential for success.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Eliseev, Roman — University of Rochester
- Study coordinator: Eliseev, Roman
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.