How mitochondrial function affects lymphatic cell development and growth
Mitochondrial respiration as a regulator of lymphatic cell fate and therapeutic lymphangiogenesis
['FUNDING_R01'] · NORTHWESTERN UNIVERSITY AT CHICAGO · NIH-10878790
This study is looking at how the energy production in certain cells affects the growth of lymphatic vessels, which are important for our body's fluid balance, especially after heart injuries or pancreatitis, to help find new ways to treat related health issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY AT CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10878790 on ClinicalTrials.gov |
What this research studies
This research investigates the role of mitochondrial respiration in the development and function of lymphatic endothelial cells, which are crucial for the formation of lymphatic vessels. By using mouse models, the study aims to understand how changes in mitochondrial activity influence lymphangiogenesis, particularly in response to conditions like cardiac injury and pancreatitis. The research focuses on how the metabolic state of these cells can dictate their fate and function, potentially leading to new therapeutic strategies for diseases involving lymphatic dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions affecting the lymphatic system, particularly those over 21 years old.
Not a fit: Patients with non-lymphatic related conditions or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for conditions related to lymphatic system dysfunction, improving patient outcomes.
How similar studies have performed: Previous research has shown that targeting endothelial cell metabolism can influence vascular development, suggesting a promising avenue for this investigation.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY AT CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: OLIVER, GUILLERMO C — NORTHWESTERN UNIVERSITY AT CHICAGO
- Study coordinator: OLIVER, GUILLERMO C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.