How mitochondria influence healing after injury
Official title: Mitochondrial function regulates ROS-mediated patterning following injury
Funded at Mainehealth · NIH-11055462 · Data updated 2026-11-12
This study is looking at how tiny parts of our cells called mitochondria help with healing, especially when it comes to regrowing lost body parts, like a fingertip, by focusing on certain proteins that might help guide the healing process.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mainehealth NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | March 15, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $562,524 |
| NIH project number | 5R01HD112474-02 |
| Project ID | NIH-11055462 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced limb injuries or amputations and are interested in regenerative therapies.
✕Less likely to help
Patients with chronic non-healing wounds or those who do not have limb injuries may not benefit from this research.
What this research studies
This research investigates the role of mitochondria in healing processes, particularly focusing on how they generate reactive oxygen species (ROS) that aid in limb regeneration. By using a mouse model of digit tip amputation, the study aims to understand the functions of specific mitochondrial proteins, BNIP3 and NIX, in promoting tissue regeneration. The researchers will explore how these proteins interact to create signaling gradients that guide the healing process, potentially leading to new insights into regenerative medicine.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance healing and regeneration in patients with injuries or amputations.
How similar studies have gone: Previous research has shown promising results in understanding mitochondrial roles in regeneration, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Mainehealth
Portland, United States Active
Researchers
- Principal investigator: Guntur, Anyonya R — Mainehealth
- Study coordinator: Guntur, Anyonya R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.