How mitochondria help protect the body during infections
Mechanisms of host protection during infection via the mitochondrial unfolded protein response
This study looks at how tiny parts of our cells, called mitochondria, help our bodies fight off bacterial infections by activating a special protective response, and it's designed for anyone interested in understanding how this process can boost our immune system and improve recovery from illness.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Arlington NIH-funded |
| Lab location | 1 site (Arlington, United States) |
| Project ID | NIH-11044069 on NIH RePORTER |
What this research studies
This research investigates how mitochondria, the energy-producing structures in cells, respond to bacterial infections. It focuses on the mitochondrial unfolded protein response (UPRmt), a protective mechanism that helps cells recover from stress caused by pathogens. By studying this response, the research aims to understand how it enhances the immune system's ability to fight infections and improve survival rates. The approach involves using animal models to observe the effects of UPRmt activation on infection outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with bacterial infections, especially those caused by antibiotic-resistant strains.
Not a fit: Patients with viral infections or those not affected by bacterial infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing the immune response against bacterial infections, particularly those caused by antibiotic-resistant bacteria.
How similar studies have performed: Other research has shown promising results in understanding mitochondrial responses to infections, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
Arlington, United States
- University of Texas Arlington — Arlington, United States (Active)
Researchers
- Principal investigator: Pellegrino, Mark Watson — University of Texas Arlington
- Study coordinator: Pellegrino, Mark Watson
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.