How mitochondria help immune cells fight infections
Mitochondrial Calcium Signaling in Cell Intrinsic Immunity
This study is looking at how certain immune cells use signals from their energy factories to quickly produce the energy they need to fight off infections like Candida albicans, which could help us find better ways to boost our immune system and tackle infections more effectively.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11116855 on NIH RePORTER |
What this research studies
This research investigates how immune cells, specifically phagocytes, use mitochondrial calcium signaling to quickly generate energy needed to kill pathogens like Candida albicans. By examining the interactions between mitochondria and phagosomes, the study aims to uncover the mechanisms that allow immune cells to respond rapidly to infections. The research involves detailed analysis of cellular processes and signaling pathways that enhance the immune response, potentially leading to new therapeutic strategies. Patients may benefit from insights gained about improving immune function and combating infections more effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with compromised immune systems or those at high risk for infections.
Not a fit: Patients with fully functioning immune systems and no history of recurrent infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the immune system's ability to fight infections.
How similar studies have performed: Other research has shown promising results in understanding mitochondrial functions in immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Desai, Bimal N. — University of Virginia
- Study coordinator: Desai, Bimal N.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.