How mitochondria affect vision loss after brain injuries
Mitochondria: controllers of trauma-induced secondary neurodegeneration onset
This study is looking at how brain injuries can affect vision by damaging the nerves that connect the eyes to the brain, and it aims to find ways to protect and improve vision for people who have experienced these injuries, like those with indirect traumatic optic neuropathy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10905349 on NIH RePORTER |
What this research studies
This research investigates the role of mitochondria in secondary neurodegeneration that occurs after traumatic brain injuries (TBI) and its impact on vision loss. It focuses on a specific condition known as indirect traumatic optic neuropathy (ITON), which can lead to permanent vision loss in some patients. By studying mouse models, the research aims to identify the timing and mechanisms of secondary axon degeneration and explore potential therapeutic interventions, such as vitamin E, to protect vision. The goal is to find effective treatments for patients suffering from vision loss due to brain trauma.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have suffered a traumatic brain injury and are at risk for vision loss due to indirect traumatic optic neuropathy.
Not a fit: Patients who have not experienced a traumatic brain injury or those with other unrelated vision issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent vision loss in patients who have experienced traumatic brain injuries.
How similar studies have performed: Previous research has shown promising results in similar models, indicating that targeting mitochondrial dysfunction could be a viable approach to treating optic neuropathies.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Rex, Tonia S — Vanderbilt University Medical Center
- Study coordinator: Rex, Tonia S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.