How mitochondria affect immune cells after a heart attack
Mitochondrial metabolism and macrophage function post MI
This study is looking at how certain immune cells called macrophages help the heart heal after a heart attack, with the hope of finding new ways to support recovery and improve heart health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10630833 on NIH RePORTER |
What this research studies
This research investigates the role of macrophages, a type of immune cell, in heart health following a heart attack (myocardial infarction). It focuses on how these cells change their function and metabolism in response to the injury, particularly looking at the shift from a proinflammatory state to a reparative one. By analyzing the metabolic pathways of macrophages during the recovery phase, the study aims to uncover mechanisms that could influence healing and remodeling of the heart. This could lead to new therapeutic strategies to improve recovery after heart attacks.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have recently experienced a myocardial infarction.
Not a fit: Patients who have not had a heart attack or those with chronic heart conditions unrelated to recent myocardial infarction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance heart recovery and reduce complications after a heart attack.
How similar studies have performed: Previous research has shown that targeting macrophage function and metabolism can lead to significant improvements in heart recovery, indicating a promising avenue for this investigation.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Tian, Rong — University of Washington
- Study coordinator: Tian, Rong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.