How mitochondria affect heart cell signaling
Regulation of compartmentalized cAMP signaling by mitochondria-associated spaces in adult ventricular myocytes
This study is looking at how tiny parts of heart cells, called mitochondria, help control a key molecule that affects heart function, with the goal of finding better treatments for heart problems like arrhythmias and heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nevada Reno NIH-funded |
| Lab location | 1 site (Reno, United States) |
| Project ID | NIH-10862824 on NIH RePORTER |
What this research studies
This research investigates how mitochondria influence the signaling pathways in heart cells, specifically focusing on the regulation of cAMP, a molecule that plays a crucial role in heart function. By understanding how cAMP is compartmentalized within heart cells, the study aims to uncover mechanisms that could lead to better treatments for heart diseases such as arrhythmias and heart failure. The researchers will use advanced computational models and experimental techniques to explore the physical barriers within cells that affect cAMP movement and signaling. This could provide insights into how heart cells communicate and respond to various stimuli.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who have cardiovascular diseases, particularly those with arrhythmias or heart failure.
Not a fit: Patients with non-cardiovascular conditions or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating serious heart conditions.
How similar studies have performed: Previous research has shown that understanding cellular signaling pathways can lead to significant advancements in treating cardiovascular diseases, suggesting that this approach has potential for success.
Where this research is happening
Reno, United States
- University of Nevada Reno — Reno, United States (Active)
Researchers
- Principal investigator: Agarwal, Shailesh — University of Nevada Reno
- Study coordinator: Agarwal, Shailesh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.