How mitochondria adapt to stress in brain cancer cells
Official title: Mitochondria electron transport chain complexes adaptative responses to cellular stress
Funded at University of Iowa · NIH-10862710 · Data updated 2026-11-12
This study is looking at how glioblastoma cells become resistant to radiation treatment by exploring changes in their energy-producing structures, which could help find better ways to make radiation therapy work more effectively for patients with this type of brain cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $425,286 |
| NIH project number | 5R01NS129702-02 |
| Project ID | NIH-10862710 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with glioblastoma who are undergoing or have undergone radiotherapy.
✕Less likely to help
Patients with other types of cancer or those who have not been diagnosed with glioblastoma may not benefit from this research.
What this research studies
This research investigates how glioblastoma cells develop resistance to radiotherapy by examining the role of mitochondrial electron transport chain complexes. It aims to understand how these complexes rearrange into supercomplexes in response to cellular stress, which may alter the cells' energy production and reduce harmful byproducts. The study will utilize glioma cell lines, patient-derived models, and tumor samples to explore these mechanisms and identify potential therapeutic targets. By understanding these processes, the research seeks to uncover new strategies to enhance the effectiveness of radiotherapy for glioblastoma patients.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for glioblastoma, potentially overcoming resistance to radiotherapy.
How similar studies have gone: Previous research has shown promising results in understanding mitochondrial functions in cancer, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Griguer, Corinne E. — University of Iowa
- Study coordinator: Griguer, Corinne E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.