How misfolded proteins spread in certain types of dementia
S-Nitrosylation-Dependent Pathological Spread of Abnormal Proteins in Frontotemporal Dementia and Lewy Body Dementia
This study is looking at how certain misfolded proteins spread between cells and cause damage in diseases like Alzheimer's and Lewy body dementia, with the hope of finding new ways to diagnose and treat these conditions to help patients feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10984954 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which misfolded proteins, such as TDP-43 and α-synuclein, spread between cells in neurodegenerative diseases like Alzheimer's, Lewy body dementia, and frontotemporal dementia. The study focuses on understanding how these proteins cause cellular damage and contribute to disease progression. By examining the role of S-nitrosylation in this process, the researchers aim to uncover new diagnostic and therapeutic strategies. Patients may benefit from insights that could lead to more effective treatments for these debilitating conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease, Lewy body dementia, or frontotemporal dementia.
Not a fit: Patients with other types of dementia not related to the misfolded proteins studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostics and therapies for patients suffering from various forms of dementia.
How similar studies have performed: Previous research has shown promising results in understanding protein aggregation and its implications in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Nakamura, Tomohiro — Scripps Research Institute, the
- Study coordinator: Nakamura, Tomohiro
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.