How mineralocorticoid receptors affect muscle healing and injury response
Functions of skeletal muscle mineralocorticoid receptor signaling in chronic and acute injury
This study is looking at how certain receptors in your muscles affect healing after an injury, especially how they might help or hurt the recovery process, and it's being tested in mice to find better ways to support muscle repair for people like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10975160 on NIH RePORTER |
What this research studies
This research investigates the role of mineralocorticoid receptors (MRs) in skeletal muscle, particularly how they influence the behavior of fibroblasts during muscle injury and healing. By examining the effects of MR antagonists on muscle pathology, the study aims to understand how these receptors contribute to fibrosis, which can impair muscle function. The research utilizes mouse models to explore the complex interactions between different cell types in the muscle environment, focusing on how MR signaling can either promote or inhibit fibrosis and muscle repair.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with Duchenne muscular dystrophy or other conditions that involve muscle fibrosis.
Not a fit: Patients without muscle-related conditions or those not experiencing fibrosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions like Duchenne muscular dystrophy by targeting fibrosis in skeletal muscle.
How similar studies have performed: Previous research has shown that targeting mineralocorticoid receptors can have therapeutic benefits in heart failure, suggesting potential for success in similar approaches for muscle conditions.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Rafael-Fortney, Jill a — Ohio State University
- Study coordinator: Rafael-Fortney, Jill a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.