How Microsporidia Germs Infect Cells
Microsporidia: invasion apparatus
['FUNDING_R01'] · ALBERT EINSTEIN COLLEGE OF MEDICINE · NIH-11092825
This research explores how tiny germs called microsporidia, which can cause serious infections in people with weakened immune systems like those with AIDS, enter human cells.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ALBERT EINSTEIN COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (BRONX, UNITED STATES) |
| Trial ID | NIH-11092825 on ClinicalTrials.gov |
What this research studies
Microsporidia are tiny parasites related to fungi that can cause infections, especially in people with weakened immune systems, such as those with AIDS or organ transplants. These infections can lead to problems like chronic diarrhea, brain issues, muscle pain, or eye problems. The germs get into cells using a unique tool called a polar tube, which acts like a tiny harpoon. This project aims to understand the 3D structure of this polar tube and how it works to invade host cells. By learning more about this invasion process, we hope to find new ways to stop these infections.
Who could benefit from this research
Good fit: This research is relevant to patients with weakened immune systems, such as those with AIDS or organ transplants, who are at risk for microsporidia infections.
Not a fit: Patients who are not at risk for microsporidia infections or who have healthy immune systems may not directly benefit from this specific research.
Why it matters
Potential benefit: Understanding how these germs invade cells could lead to new treatments or ways to prevent microsporidia infections, especially for vulnerable patients.
How similar studies have performed: While microsporidia have been studied for a long time, the exact mechanism of polar tube invasion is still unknown, making this a fundamental and novel area of investigation.
Where this research is happening
BRONX, UNITED STATES
- ALBERT EINSTEIN COLLEGE OF MEDICINE — BRONX, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WEISS, LOUIS M. — ALBERT EINSTEIN COLLEGE OF MEDICINE
- Study coordinator: WEISS, LOUIS M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome, Acquired Immunodeficiency Syndrome Virus